1.) Some items are more useful than they appear. In past games there was a lot of junk just laying around wasn't particularly useful. Now, those items are well worth picking up and lugging around. Here are some that you should definitely grab:
--Duct tape/Wonderglue: Breaks down into adhesives which are used in both weapon and armor mods. It's a good idea to keep a good supply on hand so you can pimp out any new gear you find.
--Aluminum Cans/TV Dinner Trays/Trays: Early in the game you gain access to some Power Armor. Power Armor is great but it requires more maintenance and items than regular armor. Unlike regular armor it also requires repair which is done primarily with aluminum. Keep your eyes peeled for those silvery cans and dirty TV Dinner Trays and be sure to pick them up. The fish packing plants (I've come across two--the Four Leaf Clover plant and another one in the far northeastern corner of the map) are a great source of trays for aluminum.
--Abraxo Cleaner: Breaks down into antiseptic which is one of the main components to craft your own stimpacks. You can find a fairly steady supply of stimpacks out in the world, but if you plan to use them as your main source of health replenishment you may want to grab lots of Abraxo.
--Build Items/Spec Items: By this I mean specific items related to the type of build you are going for. I like to sneak around a lot so I try to find a lot of cork in order to make my gear as light as possible. I've also modded out my gear so that it is shadowed which allows even better sneaking. I loot every single globe that I see because they are a great source of cork.
--Hot plates, telephones, desk fans, typewriters: These items tend to break down into a lot of different and very useful parts. The downside is that they are generally heavy. If you intend to build happy settlements grab all that goofy pre-war stuff.
--Armor/Weapons with special components: The build for my current character didn't involve the skills or perks that allow for both full weapon and armor modification talents. As a result I've resorted to pinching useful mods from looted weapons or armor. My advice is to pick up any items that have a mod that you might be interested in. If a piece of loot has a particularly long name it's probably worth grabbing just so you can cannibalize it for mods.
--Meat: Preparing food requires no special skills. Most prepared food also gives you a handy buff for a specific amount of time. Cooked food contains no radiation unlike most of the other food you will find in the world.
Those are the main items I can think of at the moment. I'm sure there are way more that I'm forgetting.
2.) Your settlement doesn't have to be fancy. Settlers are completely fine with sleeping in a sleeping bag which requires few components compared to building a bed. They also take up less space. Building the basics for your settlement is good enough. (I'm not content with simply slapping down some sleeping bags and have, for completely no reason, tried to decorate and make my settlements a weird version of Martha Stewart-esque Fallout zones. My settlers don't appreciate my sense of post-apocalyptic style and are stuck at 80 happiness)
3.) Dogmeat can equip certain items! This took way longer to figure out than I care to admit. There are a variety of dog related items that you can loot in order to give your canine companion a unique look. Bandanas, collars, chains, and even dog armor can all complete the look for Dogmeat. I was very excited when I came across my first set of dog armor...only to realize that it's purely cosmetic and doesn't do anything. My Dogmeat sports a fun red bandana as seen here!
4.) You can buy another dog! Last night I found a guy walking near the Red Rocket Gas Station (the first one you discover near Sanctuary) and he offered to sell me a dog for 250 caps. I managed to pass a low-level charisma check and convinced him that I would take care of the dog. After purchasing the dog you can send it to any of your settlements. Having a dog in your settlement will provide 5 additional defense.
5.) Recon scopes are handy. Even if you don't intend to do any sniping, grabbing a rife with a recon scope will allow you to mark enemies on your HUD. This has been very useful in planning attacks from afar.
6.) Your companions are basically pack mules...use them accordingly. Poor Dogmeat is usually burdened with all the junk and weapons I don't want to carry around.
--Duct tape/Wonderglue: Breaks down into adhesives which are used in both weapon and armor mods. It's a good idea to keep a good supply on hand so you can pimp out any new gear you find.
--Aluminum Cans/TV Dinner Trays/Trays: Early in the game you gain access to some Power Armor. Power Armor is great but it requires more maintenance and items than regular armor. Unlike regular armor it also requires repair which is done primarily with aluminum. Keep your eyes peeled for those silvery cans and dirty TV Dinner Trays and be sure to pick them up. The fish packing plants (I've come across two--the Four Leaf Clover plant and another one in the far northeastern corner of the map) are a great source of trays for aluminum.
--Abraxo Cleaner: Breaks down into antiseptic which is one of the main components to craft your own stimpacks. You can find a fairly steady supply of stimpacks out in the world, but if you plan to use them as your main source of health replenishment you may want to grab lots of Abraxo.
--Build Items/Spec Items: By this I mean specific items related to the type of build you are going for. I like to sneak around a lot so I try to find a lot of cork in order to make my gear as light as possible. I've also modded out my gear so that it is shadowed which allows even better sneaking. I loot every single globe that I see because they are a great source of cork.
--Hot plates, telephones, desk fans, typewriters: These items tend to break down into a lot of different and very useful parts. The downside is that they are generally heavy. If you intend to build happy settlements grab all that goofy pre-war stuff.
--Armor/Weapons with special components: The build for my current character didn't involve the skills or perks that allow for both full weapon and armor modification talents. As a result I've resorted to pinching useful mods from looted weapons or armor. My advice is to pick up any items that have a mod that you might be interested in. If a piece of loot has a particularly long name it's probably worth grabbing just so you can cannibalize it for mods.
--Meat: Preparing food requires no special skills. Most prepared food also gives you a handy buff for a specific amount of time. Cooked food contains no radiation unlike most of the other food you will find in the world.
Those are the main items I can think of at the moment. I'm sure there are way more that I'm forgetting.
2.) Your settlement doesn't have to be fancy. Settlers are completely fine with sleeping in a sleeping bag which requires few components compared to building a bed. They also take up less space. Building the basics for your settlement is good enough. (I'm not content with simply slapping down some sleeping bags and have, for completely no reason, tried to decorate and make my settlements a weird version of Martha Stewart-esque Fallout zones. My settlers don't appreciate my sense of post-apocalyptic style and are stuck at 80 happiness)
 |
| Dogmeat with his cute lil' bandana. |
4.) You can buy another dog! Last night I found a guy walking near the Red Rocket Gas Station (the first one you discover near Sanctuary) and he offered to sell me a dog for 250 caps. I managed to pass a low-level charisma check and convinced him that I would take care of the dog. After purchasing the dog you can send it to any of your settlements. Having a dog in your settlement will provide 5 additional defense.
5.) Recon scopes are handy. Even if you don't intend to do any sniping, grabbing a rife with a recon scope will allow you to mark enemies on your HUD. This has been very useful in planning attacks from afar.
6.) Your companions are basically pack mules...use them accordingly. Poor Dogmeat is usually burdened with all the junk and weapons I don't want to carry around.
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